Journal Articles

Recent Representative Publications (View)

242. Wei Liu+, Yanfang Wang+, Jinqiang Wang*, Olivia L. Lanier, Marissa E. Wechsler, Nicholas A. Peppas* , Zhen Gu*

Macroencapsulation Devices for Cell Therapy, Engineering, in press, 2021

241. Jicheng Yu, Yuqi Zhang* and Zhen Gu*

Treating diabetes with “cookies”, Nature Chemical Biology, in press, 2021

240. Hongjun Li+, Zejun Wang+, Edikan Archibong, Qing Wu, Guojun Chen, Quanyin Hu, Tianyuan Ci, Zhaowei Chen, Jinqiang Wang, Di Wen, Hongwei Du, Jie Jiang, Jie Sun, Xingcai Zhang, Gianpietro Dotti*, Zhen Gu*

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy, National Science Review, in press, 2021

DOI: 10.1093/nsr/nwab172

239. Dong Cen, Qiwei Ge, Congkun Xie, Qiang Zheng, Jiansheng Guo, Yuqi Zhang, Yifan Wang, Xiang Li*, Zhen Gu*, Xiujun Cai*

ZnS@BSA Nanoclusters Potentiate Efficacy of Cancer Immunotherapy, Advanced Materials, in press, 2021

238. Ruyi Zhou, Jicheng Yu, Yuqi Zhang*, Zhen Gu*

Microneedle-Mediated Therapy for Cardiovascular Diseases, Drug Delivery and Translational Research, in press, 2021

237. Edikan A. Ogunnaike, Alain Valdivia, Mostafa Yazdimamaghani, Ernesto Leon, Seema Nandi, Hannah Hudson, Hongwei Du, Simon Khagi, Zhen Gu, Barbara Savoldo, Frances Ligler, Shawn Hingtgen, Gianpietro Dotti*

Fibrin Gel Enhances the Antitumor Effects of Chimeric Antigen Receptor T Cells in Glioblastoma, Science Advances, in press, 2021

236. Yixin Wang, Zhaoting Li, Fanyi Mo, Zhen Gu*, Quanyin Hu*

Engineered platelets: advocates for tumor immunotherapy, Nano Today, in press, 2021

235. Hao Wang, Tao Sheng, Sheng Zhao, Yi Zheng, Jicheng Yu, Yuqi Zhang*, Zhen Gu*

Recent Advances in Transdermal Sensors for Glucose Monitoring, Current Opinion in Biomedical Engineering, in press, 2021

DOI: 10.1016/j.cobme.2021.100326

234. Tao Sheng, Bowen Luo, Wentao Zhang, Xinyang Ge, Jicheng Yu, Yuqi Zhang*, Zhen Gu*

Microneedle-Mediated Vaccination: Innovation and Translation, Advanced Drug Delivery Reviews, in press, 2021

DOI: 10.1016/j.addr.2021.113919

233. Ting Huang+, Tianyuan Zhang+*, Xinchi Jiang, Ai Li, Yuanqin Su, Qiong Bian, Honghui Wu, Ruyi Lin, Ni Li, Hongcui Cao, Daishun Ling, Jinqiang Wang, Yasuhiko Tabata, Zhen Gu*, Jianqing Gao*

Iron oxide nanoparticles augment the intercellular mitochondrial transfer mediated therapy, Science Advances, in press, 2021

232. Xue Xia, Bingyang Shi*, Lei Wang, Yang Liu, Yan Zou, Yun Zhou,Yu Chen, Meng Zheng, Yingfang Zhu, Jingjing Duan, Siyi Guo, Ho Won Jang, Yuchen Miao, Kelong Fan, Feng Bai, Wei Tao, Yong Zhao, Qingyu Yan, Gang Cheng, Huiyu Liu, Yan Jiao, Shanhu Liu, Yuanyu Huang, Daishun Ling, Wenyi Kang, Xue Xue, Daxiang Cui, Yongwei Huang, Zongqiang Cui, Xun Sun, Zhiyong Qian, Zhen Gu, Gang Han, Zhimou Yang, David Tai Leong, Aiguo Wu, Gang Liu, Xiaogang Qu, Youqing Shen, Qiangbin Wang, Gregory V. Lowry, Ertao Wang, Xing-Jie Liang, Jorge Gardea-Torresdey, Guoping Chen, Wolfgang J. Parak, Paul S. Weiss, Lixin Zhang, Martina M. Stenzel, Chunhai Fan, Ashley I. Bush, Gaiping Zhang, Christopher P.L. Grof, Xuelu Wang, David W. Galbraith, Ben Zhong Tang, Christina E.Offler*, John W. Patrick*, Chun-Peng Song*

From Mouse to Mouse-Ear Cress: Nanomaterials as Vehicles in Plant Biotechnology, Exploration, in press, 2021

DOI: 10.1002/exp2.0210002

231. Wentao Zhang, Tao Sheng, Zhen Gu*, Yuqi Zhang*

Strategies for Browning Agent Delivery, Pharmaceutical Research, in press, 2021

230. Guojun Chen+, Zhitong Chen+, Zejun Wang, Richard Obenchain, Di Wen, Hongjun Li, Richard E. Wirz*, and Zhen Gu*

Portable air-fed cold atmospheric plasma device for post-surgical cancer treatment, Science Advances, in press, 2021

229. Brigitta Loretz*, Yu-Kyoung Oh*, Sarah Hudson*, Zhen Gu*, Claus-Michael Lehr*

Infectious Diseases as a Global Threat – Challenges and Opportunities for Drug Delivery Science, Drug Delivery and Translational Research, 11(1316), 2021

DOI: 10.1007/s13346-021-01009-1

228. Rajesh Paul, Emily Ostermann, Yuting Chen, Amanda C. Saville, Yuming Yang, Zhen Gu, Anna E. Whitfield, Jean B. Ristaino, Qingshan Wei*

Integrated Microneedle-Smartphone Nucleic Acid Amplification Platform for In-Field Diagnosis of Plant Diseases, Biosensors and Bioelectronics, 187(113312), 2021

DOI: 10.1016/j.bios.2021.113312

227. Zhaowei Chen+, Hongjun Li+, Yijie Bian, Zejun Wang, Guojun Chen, Xudong Zhang, Yimin Miao, Di Wen, Jinqiang Wang, Gang Wan, Yi Zeng, Peter Abdou, Jun Fang, Song Li, Cheng-Jun Sun, and Zhen Gu*

Bioorthogonal catalytic patch, Nature Nanotechnology, 16(933), 2021

DOI: 10.1038/s41565-021-00910-7

226. Tingxizi Liang, Di Wen, Guojun Chen, Amanda Chan, Zhaowei Chen, Hongjun Li, Zejun Wang, Xiao Han, Liping Jiang*, Jun-Jie Zhu* and Zhen Gu*

Adipocyte-Derived Anticancer Lipid Droplet, Advanced Materials, 26(2100629), 2021

DOI: 10.1002/adma.202100629

225. Hongjun Li, Zejun Wang, Zhaowei Chen, Tianyuan Ci, Guojun Chen, Di Wen, Ruoxin Li, Jinqiang Wang, Huan Meng, Richard Bell, Zhifeng Gu, Gianpietro Dotti, and Zhen Gu*

Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis, Nature Communications, 12(2773), 2021

DOI: 10.1038/s41467-021-22674-3

224. Pooyan Makvandi1*+, Rezvan Jamaledin+, Guojun Chen+, Zahra Baghbantaraghdari+, Ehsan Nazarzadeh Zare, Concetta di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu*, Robert Langer

Stimuli-responsive transdermal microneedle patches for drug delivery, Materials Today, in press, 2021

DOI: 10.1016/j.mattod.2021.03.012

223. Quanyin Hu+, Hongjun Li+, Edikan Ogunnaike, Qian Chen, Huitong Ruan, Sarah Ahn, Elena Dukhovlinova, Kang Yang, Di Wen, Gianpietro Dotti*, Zhen Gu*

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets, Nature Biomedical Engineering, in press, 2021

DOI: 10.1038/s41551-021-00712-1

222. Jinqiang Wang, Zejun Wang, Guojun Chen, Yanfang Wang, Tianyuan Ci, Hongjun Li, Xiangsheng Liu, Daojia Zhou, Anna Kahkoska, Zhuxian Zhou, Huan Meng, John Buse, Zhen Gu*

Injectable Biodegradable Polymeric Complex for Glucose-Responsive Insulin Delivery, ACS Nano, 15(4294), 2021

DOI: 10.1021/acsnano.0c07291

221. Hongjun Li, Zhen Gu*

Nanodevices for cancer vaccination, Nature Materials, 20(286), 2021

DOI: 10.1038/s41563-021-00941-4

220. Ruxing Fu+, Hongjun Li+, Ruoxin Li, Kyle McGrath, Gianpietro Dotti, and Zhen Gu*

Delivery Techniques for Enhancing CAR T-Cell Therapy against Solid Tumors, Advanced Functional Materials, in press, 2021

DOI: 10.1002/adfm.202009489

219. Yujie Cai, Wei Bing,* Xiao Xu, Yuqi Zhang, Zhaowei Chen, Zhen Gu*

Topographical nanostructures for physical sterilization, Drug Delivery and Translational Research, in press, 2021

DOI: 10.1007/s13346-021-00906-9

218. Xing Jiang, Li Ren, Peyton Tebon, Canran Wang, Xingwu Zhou, Moyuan Qu, Jixiang Zhu, Haonan Ling, Shiming Zhang, Yumeng Xue, Qingzhi Wu, Praveen Bandaru, Junmin Lee, Han-Jun Kim, Samad Ahadian, Nureddin Ashammakhi, Mehmet R. Dokmeci, Jinhui Wu, Zhen Gu, Wujin Sun* and Ali Khademhosseini*

Cancer-on-a-chip for modeling immune checkpoint inhibitor and tumor interactions, Small, 17(2004282), 2021

DOI: 10.1002/smll.202004282

217. Xiuli Hu, Huijuan Zhang, Zejun Wang, Chin Ying Angela Shiu, and Zhen Gu*

Microneedle array patches integrated with nanoparticles for therapy and diagnosis, Small Structures, 4(2000097), 2021

DOI: 10.1002/sstr.202000097

216. Tianyuan Ci+, Hongjun Li+, Guojun Chen, Zejun Wang, Jinqiang Wang, Peter Abdou, Yiming Tu, Gianpietro Dotti, and Zhen Gu*

Cryo-shocked cancer cells for targeted drug delivery and vaccination, Science Advances , 6(eabc3013), 2020

DOI: 10.1126/sciadv.abc3013

215. Feng-Qin Luo+, Guojun Chen+, Wei Xu, Daojia Zhou, Jia-Xian Li, Yong-Cong Huang, Run Lin,* Zhen Gu,* Jin-Zhi Du*

Microneedle-array patch with pH-sensitive formulation for glucose-responsive insulin delivery, Nano Research, in press, 2021

DOI: 10.1007/s12274-020-3273-z

214. Zejun Wang, Jinqiang Wang, Anna R. Kahkoska, John B. Buse,* Zhen Gu*

Developing Insulin Delivery Devices with Glucose-Responsiveness, Trends in Pharmacological Sciences, 1(31), 2021

DOI: 10.1016/j.tips.2020.11.002

213. Yuqi Zhang, Jicheng Yu, Zhen Gu*

Cyborg Vessel, Matter, 5(1393), 2020

DOI: 10.1016/j.matt.2020.10.011

212. Zejun Wang, Jinqiang Wang, Hongjun Li, Jicheng Yu, Guojun Chen, Anna R. Kahkoska, Valerie Wu, Yi Zeng, Di Wen, Jayson R. Miedema, John B. Buse, Zhen Gu*

Dual self-regulated delivery of insulin and glucagon by a hybrid patch, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 117(29512), 2020

DOI: 10.1073/pnas.2011099117

211. Yi Zeng, Jinqiang Wang, Zejun Wang, Guojun Chen, Jicheng Yu, Sen Li, Qiwei Li, Hongjun Li, Di Wen, Zhongze Gu,* and Zhen Gu*

Colloidal crystal microneedle patch for glucose monitoring, Nano Today, 35(100984), 2020

DOI: 10.1016/j.nantod.2020.100984

210. Jinhua Li,* Xinquan Jiang, Hongjun Li, Michael Gelinsky, and Zhen Gu*

Tailoring Materials for Modulation of Macrophage Fate, Advanced Materials, 12(2004172), 2021

DOI: 10.1002/adma.202004172

209. Xingwu Zhou, Xing Jiang, Moyuan Qu, George Aninwene II, Vadim Jucaud, James J. Moon, Zhen Gu, Wujin Sun,* Ali Khademhosseini*

Engineering Antiviral Vaccines, ACS Nano, 10(12370), 2020

DOI: 10.1021/acsnano.0c06109

208. Xiao Han, Hongjun Li, Daojia Zhou, Zhaowei Chen,* Zhen Gu*

Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics, Accounts of Chemical Research, 11(2521), 2020

DOI: 10.1021/acs.accounts.0c00339

207. Guojun Chen+, Zhitong Chen+, Di Wen, Zejun Wang, Hongjun Li, Yi Zeng, Gianpietro Dotti, Richard Wirz*, Zhen Gu*

Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 7(3687), 2020

DOI: 10.1073/pnas.1917891117

206. Jicheng Yu, Jinqiang Wang, Yuqi Zhang, Guojun Chen, Weiwei Mao, Yanqi Ye, Anna R. Kahkoska, John B. Buse, Robert Langer and Zhen Gu*

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs, Nature Biomedical Engineering, 4(499), 2020 (Cover Feature)

DOI: 10.1038/s41551-019-0508-y

205. Xuexiang Zhang, Tae-Hyung Kim, Timothy J. Thauland, Hongjun Li, Fatemeh Sadat Majedi, Chau Ly, Zhen Gu, Manish J. Butte, Amy C. Rowat, Song Li*

Unraveling the Mechanobiology of Immune Cells, Current Opinion in Biotechnology, 66(236), 2020

DOI: 10.1016/j.copbio.2020.09.004

204. Moyuan Qu, Han-Jun Kim, Xingwu Zhou, Canran Wang, Xing Jiang, Jixiang Zhu, Yumeng Xue, Peyton Tebon, Shima A. Sarabi, Samad Ahadian, Mehmet R. Dokmeci, Songsong Zhu, Zhen Gu, Wujin Sun,* and Ali Khademhosseini*

Biodegradable Microneedle Patch for Transdermal Gene Delivery, Nanoscale, 12(16724), 2020

DOI: 10.1039/D0NR02759F

203. Tingxizi Liang, Di Wen, Xintong Zhong, Jun-Jie Zhu*, Zhen Gu*

Therapeutic Potential of Adipose Tissue, Science Bulletin, 20(1702), 2020

DOI: 10.1016/j.scib.2020.06.037

202. Rezvan Jamaledin+, Cynthia K.Y. Yiu+, Ehsan N. Zare+, Li-na Niu, Raffaele Vecchione, Guojun Chen, Zhen Gu, Franklin R. Tay*, Pooyan Makvandi*

Advances in antimicrobial microneedle patches for combating infections, Advanced Materials, 33(2002129), 2020

DOI: 10.1002/adma.202002129

201. Qingle Ma, Qin Fan, Jialu Xu, Jinyu Bai, Xiao Han, Ziliang Dong, Xiaozhong Zhou, Zhuang Liu, Zhen Gu*, and Chao Wang*

Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-Derived Extracellular Vesicles, Matter, 3(1), 2020

DOI: 10.1016/j.matt.2020.05.017

200. Lauren R. Richter, Qianfen Wan, Di Wen, Yuqi Zhang, Junjie Yu, Jin ku Kang, Changyu Zhu, Elizabeth L. McKinnon, Zhen Gu*, Li Qiang*, and Utpal B. Pajvani*

Targeted Delivery of Notch Inhibitor Attenuates Obesity-induced Glucose Intolerance and Liver Fibrosis, ACS Nano, 6(6878), 2020

DOI: 10.1021/acsnano.0c01007

199. Guang Yang*, Guojun Chen, Zhen Gu*

Transdermal drug delivery for hair regrowth, Molecular Pharmaceutics, 2(483), 2020

DOI: 10.1021/acs.molpharmaceut.0c00041

198. Jie Gao, Zhen Gu*

Toward nanoscopic cellular imaging by X-ray, National Science Review, nwaa206, 2020 (Research Highlights)

DOI: 10.1093/nsr/nwaa206

197. Xudong Zhang, Yang Kang, Jinqiang Wang, Junjie Yan, Qian Chen, Hao Cheng*, Peng Huang*, and Zhen Gu*

PD-L1-Expressing Platelets Reverse New-Onset Type 1 Diabetes, Advanced Materials, 26(1907692), 2020

DOI: 10.1002/adma.201907692

196. Xingwu Zhou, Zhimin Luo, Avijit Baidya, Hanjun Kim, Canran Wang, Xing Jiang, Moyuan Qu, Jixiang Zhu, Li Ren, Fereshteh Vajhadin, Peyton Tebon, Niyuan Zhang, Yumeng Xue, Yudi Feng, Chengbin Xue, Yi Chen, KangJu Lee, Junmin Lee, Shiming Zhang, Chun Xu, Nureddin Ashammakhi, Samad Ahadian, Mehmet Remzi Dokmeci, Zhen Gu, Wujin Sun*, Ali Khademhosseini*

Biodegradable beta-cyclodextrin conjugated gelatin methacryloyl microneedle for delivery of water-insoluble drug, Advanced Healthcare Materials, 11(2000527), 2020

DOI: 10.1002/adhm.202000527

195. Wujin Sun*, Jinqiang Wang, Quanyin Hu, Xingwu Zhou, Ali Khademhosseini, Zhen Gu*

CRISPR-Cas12a delivery by DNA-mediated bio-responsive editing for cholesterol regulation, Science Advances, 21(eaba2983), 2020

DOI: 10.1126/sciadv.aba2983

194. Peter Abdou, Zejun Wang, Qian Chen*, Amanda Chan, Daojia Rosie Zhou, Vivienne Gunadhi, Zhen Gu*

Advances in Engineering Local Drug Delivery Systems for Cancer Immunotherapy, WIREs Nanomedicine & Nanobiotechnology, 5(e1632), 2020

DOI: 10.1002/wnan.1632

193. Zejun Wang+, Hongjun Li+, Jinqiang Wang, Zhaowei Chen, Guojun Chen, Di Wen, Amanda Chan, Zhen Gu*

Transdermal Colorimetric Patch for Hyperglycemia Sensing in Diabetic Mice, Biomaterials, 237(119782), 2020

DOI: 10.1016/j.biomaterials.2020.119782

192. Zhaowei Chen*, Di Wen, Zhen Gu*

Cargo-Encapsulated Cells for Drug Delivery, Science China Life Sciences, 63(599), 2020

DOI: 10.1007/s11427-020-1653-y

191. Rajesh Paul, Emily Ostermann, Zhen Gu, Jean B. Ristaino, Qingshan Wei*

DNA Extraction from Plant Leaves Using a Microneedle Patch, Current Protocols in Plant Biology, 1(e20104), 2020

DOI: 10.1002/cppb.20104

190. Jixiang Zhu, Xingwu Zhou, Han-Jun Kim, Moyuan Qu, Xing Jiang, KangJu Lee, Li Ren, Qingzhi Wu, Canran Wang, Xunmin Zhu, Peyton Tebon, Shiming Zhang, Junmin Lee, Nureddin Ashammakhi, Samad Ahadian, Mehmet Remzi Dokmeci, Zhen Gu, Wujin Sun* and Ali Khademhosseini*

Gelatin methacryloyl microneedle patches for minimally-invasive extraction of skin interstitial fluid, Small, 16(1905910), 2020

DOI: 10.1002/smll.201905910

189. Jun Fang, Yuan-Yu Hsueh, Jennifer Soto, Wujin Sun, Jinqiang Wang, Zhen Gu, Ali Khademhosseini, Song Li*

Engineering Biomaterials with Micro/Nano Technologies for Cell Reprogramming, ACS Nano, 14(1296), 2020

DOI: 10.1021/acsnano.9b04837

188. Tianyue Jiang, Guo Xu, Guojun Chen, Yu Zheng, Bingfang He* and Zhen Gu*

Progress in Transdermal Drug Delivery Systems for Cancer Therapy, Nano Research, 13(1810), 2020

DOI: 10.1007/s12274-020-2664-5

187. Tingxizi Liang, Zhaowei Chen, Zejun Wang, Jun-Jie Zhu and Zhen Gu*

Nanotechnology against Diabetes, Nanotechnology, 32(1), 2020

DOI: 10.1088/1361-6528/abaadb

186. KangJu Lee, Marcus J. Goudie, Peyton Tebon, Wujin Sun, Zhimin Luo, Junmin Lee, Shiming Zhang, Kirsten Fetah, Han-Jun Kim, Yumeng Xue, Mohammad Ali Darabi, Samad Ahadian, Einollah Sarikhani, WonHyoung Ryu, Zhen Gu, Paul S. Weiss, Mehmet R. Dokmeci, Nureddin Ashammakhi*, Ali Khademhosseini*

Non-transdermal Microneedles for Advanced Drug Delivery, Advanced Drug Delivery Reviews, 165(41), 2020

DOI: 10.1016/j.addr.2019.11.010

185. Cong-Fei Xu+,Guo-Jun Chen+,Ying-Li Luo,Yue Zhang, Gui Zhao, Zi-Dong Lu, Anna Czarnah, Zhen Gu*, Jun Wang*

Rational designs of in vivo CRISPR-Cas delivery systems, Advanced Drug Delivery Reviews, in press, 2020

DOI: 10.1016/j.addr.2019.11.005

184. Guojun Chen, Zhen Gu*

A prophylactic and a therapeutic against AML, Nature Biomedical Engineering, 4(4), 2020

DOI: 10.1038/s41551-019-0509-x

183. Yi Zeng, Jinqiang Wang*, Zhongze Gu, and Zhen Gu*

Engineering Glucose-Responsive Insulin, Medicine in Drug Discovery, 3(100010), 2019

DOI: 10.1016/j.medidd.2019.100010

182. Shuangjiang Yu*, Zhaowei Chen, Xuan Zeng, Xuesi Chen*, and Zhen Gu*

Advances in nanomedicine for cancer starvation therapy, Theranostics, 26(8026), 2019

DOI: 10.7150/thno.38261

181. Di Wen, Jinqiang Wang, George Van Den Driessche, Qian Chen, Yuqi Zhang, Guojun Chen, Hongjun Li, Jennifer Soto, Ming Liu, Masao Ohashi, Zejun Wang, Peter Abdou, Quanyin Hu, Gianpietro Dotti, Song Li, Denis Fourches, and Zhen Gu*

Adipocytes as Anticancer Drug Delivery Depot, Matter, 5(1203), 2019

DOI: 10.1016/j.matt.2019.08.007

180. Jian Jiang, Na Shen, Tianyuan Ci, Zhaohui Tang*, Zhen Gu*, Gao Li, and Xuesi Chen*

Combretastatin A4 nanodrug-induced MMP9-amplification boosts tumor-selective release doxorubicin prodrug, Advanced Materials, 44(1904278), 2019

DOI: 10.1002/adma.201904278

179. Jinqiang Wang, Zejun Wang, Jicheng Yu, Yuqi Zhang, Yi Zeng, and Zhen Gu*

A Forskolin-Conjugated Insulin Analog Targeting Endogenous Glucose-Transporter for Glucose-Responsive Insulin Delivery, Biomaterials Science, 7(4508), 2019

DOI: 10.1039/C9BM01283D

178. Xiao Xu+, Teng Li+, Shiyang Shen, Jinqiang Wang, Peter Abdou, Zhen Gu*, Ran Mo*

Advances in Engineering Cells for Cancer Immunotherapy, Theranostics, 25(7889), 2019

DOI: 10.7150/thno.38583

177. Jinqiang Wang+, Jicheng Yu+, Yuqi Zhang, Xudong Zhang, Anna R. Kahkoska, Guojun Chen, Zejun Wang, Wujin Sun, Lulu Cai, Zhaowei Chen, Chenggen Qian, Ali Khademhosseini, Qundong Shen, John B. Buse, and Zhen Gu*

Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs, Science Advances, 5(eaaw4357), 2019

DOI: 10.1126/sciadv.aaw4357

176. Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Anna R.Kahkoska, Zejun Wang, Jun Fang, Julian P. Whitelegge, Song Li, John B. Buse, and Zhen Gu*

Glucose Transporter Inhibitor-Conjugated Insulin Mitigates Hypoglycemia, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 22(10744), 2019

DOI: 10.1073/pnas.1901967116

175. Chao Wang*, Qin Fan, Zhen Gu*, Zhuang Liu*

Application of nanotechnology in cancers prevention, diagnose and treatment, Science and Technology Review, 22(96), 2018

DOI: 10.3981/j.issn.1000-7857.2018.22.008

174. Qian Chen, Tianyuan Ci, Zhen Gu*

Sprayable Gel for Post-surgical Immunotherapy, Immuno-Oncology Technology, 2(11), 2019

DOI: 10.1016/j.iotech.2019.07.001

173. Jianpei Xu, Xiaoqi Wang, Haoyuan Yin, Xiang Cao, Quanyin Hu, Wei Lv, Qunwei Xu, Zhen Gu*, Hongliang Xin*

Sequentially Site-Specific Delivery of Thrombolytic and Neuroprotectant for Enhanced Treatment of Ischemic Stroke Based on Bioengineered Nanoplatelet, ACS Nano, 8(8577), 2019

DOI: 10.1021/acsnano.9b01798

172. Qian Chen*+, Guojun Chen+, Jiawen Chen, Jingjing Shen, Xudong Zhang, Jinqiang Wang, Amanda Chan, Zhen Gu*

Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy, Nano Letters, 8(4879), 2019

DOI: 10.1021/acs.nanolett.9b00584

171. Hon S. Leong, Kimberly S. Butler, C. Jeffrey Brinker, May Azzawi, Steve Conlan, Christine Dufès, Andrew Owen, Steve Rannard, Chris Scott, Chunying Chen, Marina A. Dobrovolskaia, Serguei V. Kozlov, Adriele Prina-Mello, Ruth Schmid, Peter Wick, Fanny Caputo, Patrick Boisseau, Rachael M. Crist, Scott E. McNeil, Bengt Fadeel, Lang Tran, Steffen Foss Hansen, Nanna B. Hartmann, Lauge P. W. Clausen, Lars M. Skjolding, Anders Baun, Marlene Ågerstrand, Zhen Gu, Dimitrios A. Lamprou, Clare Hoskins, Leaf Huang, Wantong Song, Huiliang Cao, Xuanyong Liu, Klaus D. Jandt, Wen Jiang, Betty Y. S. Kim, Korin E. Wheeler, Andrew J. Chetwynd, Iseult Lynch, Sayed Moein Moghimi, André Nel, Tian Xia, Paul S. Weiss, Bruno Sarmento, José das Neves, Hélder A. Santos, Luis Santos, Samir Mitragotri, Steve Little, Dan Peer, Mansoor M. Amiji, Maria José Alonso, Alke Petri-Fink, Sandor Balog, Aaron Lee, Barbara Drasler, Barbara Rothen-Rutishauser, Stefan Wilhelm, Handan Acar, Roger G. Harrison, Chuanbin Mao, Priyabrata Mukherjee, Rajagopal Ramesh, Lacey R. McNally, Sara Busatto, Joy Wolfram, Paolo Bergese, Mauro Ferrari, Ronnie H. Fang, Liangfang Zhang, Jie Zheng, Chuanqi Peng, Bujie Du, Mengxiao Yu, Danielle M. Charron, Gang Zheng & Chiara Pastore*

On the issue of transparency and reproducibility in nanomedicine, Nature Nanotechnology, 14(629), 2019

DOI: 10.1038/s41565-019-0496-9

170. Da Huo, Jianfeng Zhu, Guojun Chen, Qian Chen, Chao Zhang, Xingyu Luo, Wei Jiang, Xiqun Jiang*, Zhen Gu*, and Yong Hu*

Eradication of unresectable liver metastasis through induction of tumour specific energy depletion, Nature Communications, 10(3051), 2019

DOI: 10.1038/s41467-019-11082-3

169. Jianlong Ji, Mangmang Li, Zhaowei Chen, Hongwang Wang, Xiaoning Jiang, Kai Zhuo, Ying Liu, Xing Yang, Zhen Gu, Shengbo Sang*, and Yang Shu*

In situ fabrication of organic electrochemical transistors on a microfluidic chip, Nano Research, 8(1943), 2019

DOI: 10.1007/s12274-019-2462-0

168. Ali Khademhosseini, Andre E. Nel, Holly Bunje, Christopher J. DeSantis, Anne M. Andrews, Rita A. Blaik, Zhen Gu, Huan Meng, Aydogan Ozcan, Sarah H. Tolbert, Tian Xia, Jeffrey I. Zink, and Paul S. Weiss*

Nanoscience and Nanotechnology at UCLA, ACS Nano, 13(6127), 2019

DOI: 10.1021/acsnano.9b04680

167. Jinqiang Wang+, Zejun Wang+, Jicheng Yu, Anna R. Kahkoska, John B. Buse, and Zhen Gu*

Glucose-responsive insulin and delivery systems: innovation and translation, Advanced Materials, 13(1902004), 2020

DOI: 10.1002/adma.201902004

166. Xiao Han, Shufang Shen, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu*, Zhen Gu*, and Chao Wang*

Red Blood Cell Derived Nanoerythrosome for Antigen Delivery with Enhanced Cancer Immunotherapy, Science Advances, 10(eaaw6870), 2019

DOI: 10.1126/sciadv.aaw6870

165. Rajesh Paul, Amanda C. Saville, Jeana C. Hansel, Yanqi Ye, Carmin Ball, Alyssa Williams, Xinyuan Chang, Guojun Chen, Zhen Gu*, Jean B. Ristaino*, and Qingshan Wei*

Extraction of Plant DNA by Microneedle Patch for Rapid Detection of Plant Diseases, ACS Nano, 6(6540), 2019

DOI: 10.1021/acsnano.9b00193

164. Zhen Gu*

Tailoring Biomaterials for Metabolic Diseases, Advanced Healthcare Materials, 12(1900632), 2019 (Editorial)

DOI: 10.1002/adhm.201900632

163. Bhanu B. Neupane*, Tao Jin, Zhen Gu, Frances S. Ligler, Gufeng Wang

Polybrominated diphenyl ethers perturb axonal growth and actin distribution, BIBECHANA, 16(64), 2019

DOI: 10.3126/bibechana.v16i0.21103

162. Quan Zhou+, Shiqun Shao+, Jinqiang Wang, Changhuo Xu, Jiajia Xiang, Ying Piao, Zhuxian Zhou, Qingsong Yu, Jianbin Tang, Xiangrui Liu, Zhihua Gan, Ran Mo, Zhen Gu*, and Youqing Shen*

Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy, Nature Nanotechnology, 14(799), 2019

DOI: 10.1038/s41565-019-0485-z

161. Lin-Lin Bu+, Junjie Yan+, Zejun Wang, Huitong Ruan, Qian Chen, Vivienne Gunadhi, R. Bryan Bell, and Zhen Gu*

Advances in Drug Delivery for Post-Surgical Cancer Treatment, Biomaterials, 219(119182), 2019

DOI: 10.1016/j.biomaterials.2019.04.027

160. Jiawei Li, Guojun Chen, Xingquan Xu, Peter Abdou, Qing Jiang, Dongquan Shi*, Zhen Gu*

Advances of Injectable Hydrogel-based Scaffolds for Cartilage Regeneration, Regenerative Biomaterials, 2(129), 2019

DOI: 10.1093/rb/rbz022

159. Zhaowei Chen, Zejun Wang, and Zhen Gu*

Bioinspired and Biomimetic Nanomedicines, Accounts of Chemical Research, 5(1255), 2019

DOI: 10.1021/acs.accounts.9b00079

158. Guang Yang, Qian Chen, Di Wen, Zhaowei Chen, Jinqiang Wang, Guojun Chen, Zejun Wang, Xudong Zhang, Yuqi Zhang, Quanyin Hu, Liang Zhang*, Zhen Gu*

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth, ACS Nano, 4(4354), 2019

DOI: 10.1021/acsnano.8b09573

157. Qian Chen, Quanyin Hu, Elena Dukhovlinova, Guojun Chen, Sarah Ahn, Chao Wang, Edikan Ogunnaike, Frances S. Ligler, Gianpietro Dotti*, Zhen Gu*

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells, Advanced Materials, 23(1900192), 2019

DOI: 10.1002/adma.201900192

156. Huitong Ruan, Quanyin Hu, Di Wen, Qian Chen, Guojun Chen, Yifei Lu, Jinqiang Wang, Hao Cheng, Weiyue Lu*, and Zhen Gu*

A Dual-Bioresponsive Drug Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade, Advanced Materials, 17(1806957), 2019

DOI: 10.1002/adma.201806957

155. Di Wen, Guojun Chen, Qian Chen, Peter Y. Li, Hao Cheng*, and Zhen Gu*

Engineering Protein Delivery Depots for Cancer Immunotherapy, Bioconjugate Chemistry, 3(515), 2019

DOI: 10.1021/acs.bioconjchem.9b00061

154. Shuangjiang Yu, Shu Wei, Liang Liu, Desheng Qi, Jiayu Wang, Guojun Chen, Wanying He, Chaoliang He*, Xuesi Chen and Zhen Gu*

Enhanced local cancer therapy by CA4P and CDDP co-loaded polypeptide gel depot, Biomaterials Science, 7(860), 2019

DOI: 10.1039/C8BM01442F

153. Linlin Bu+, Lang Rao+, Guangtao Yu, Lei Chen, Weiwei Deng, Jianfeng Liu, Hao Wu, Qianfang Meng, Shishang Guo, Xingzhong Zhao, Wenfeng Zhang, Guojun Chen, Zhen Gu, Wei Liu*, Zhijun Sun*

Cancer Stem Cell-Platelet Hybrid Membrane-Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma, Advanced Functional Materials, 10(1807733), 2019

DOI: 10.1002/adfm.201807733

152. Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, John B. Buse, Zhen Gu*

Advances in Transdermal Insulin Delivery, Advanced Drug Delivery Reviews, 139(51), 2019

DOI: 10.1016/j.addr.2018.12.006

151. Jicheng Yu, Yuqi Zhang, Jinqiang Wang, Di Wen, Anna R. Kahkoska, John B. Buse, and Zhen Gu*

Glucose-responsive oral insulin delivery for postprandial glycemic regulation, Nano Research, 7(1539), 2019

DOI: 10.1007/s12274-018-2264-9

150. Qian Chen, Chao Wang, Xudong Zhang, Guojun Chen, Quanyin Hu, Hongjun Li, Jinqiang Wang, Di Wen, Yuqi Zhang, Yifei Lu, Guang Yang, Chen Jiang, Jun Wang, Gianpietro Dotti and Zhen Gu*

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment, Nature Nanotechnology, 14(89), 2019 (Cover Feature)

DOI: 10.1038/s41565-018-0319-4

149. Junjie Yan, Xudong Zhang, Yang Liu, Yanqi Ye, Jicheng Yu, Qian Chen, Jinqiang Wang, Yuqi Zhang, Quanyin Hu, Yang Kang, Min Yang*, Zhen Gu*

Shape-Controlled Synthesis of Liquid Metal Nanodroplets for Photothermal Therapy, Nano Research, 3(1313), 2019

DOI: 10.1007/s12274-018-2262-y

148. Zhimin Luo, Wujin Sun* , Jun Fang, KangJu Lee, Song Li, Zhen Gu, Mehmet R. Dokmeci, and Ali Khademhosseini*

Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery, Advanced Healthcare Materials, 3(1801054), 2019

DOI: 10.1002/adhm.201801054

147. Huitong Ruan, Linlin Bu, Quanyin Hu, Weiyue Lu*, and Zhen Gu*

Strategies of combination drug delivery for immune checkpoint blockade, Advanced Healthcare Materials, 4(1801099), 2019

DOI: 10.1002/adhm.201801099

146. Junnan Tang, Jinqiang Wang, Ke Huang, Yanqi Ye, Teng Su, Li Qiao, Michael Taylor Hensley, Thomas George Caranasos, Jinying Zhang, Zhen Gu*, Ke Cheng*

Cardiac cell-integrated microneedle patch for treating myocardial infarction, Science Advances, 11(eaat9365), 2018

DOI: 10.1126/sciadv.aat9365

145. Yifei Lu, Quanyin Hu, Chen Jiang*, Zhen Gu*

Platelet for Drug Delivery, Current Opinion in Biotechnology, 58(81), 2019

DOI: 10.1016/j.copbio.2018.11.010

144. Quanyin Hu, Wujin Sun, Jinqiang Wang, Huitong Ruan, Xudong Zhang, Yanqi Ye, Song Shen, Chao Wang, Weiyue Lu, Ke Cheng, Gianpietro Dotti, Joshua F. Zeidner, Jun Wang, and Zhen Gu*

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy, Nature Biomedical Engineering, 2(831), 2018

DOI: 10.1038/s41551-018-0310-2

143. Penghe Zhao, Zhaokui Jin, Qian Chen, Tian Yang, Danyang Chen, Jin Meng, Xifeng Lu, Zhen Gu*, Qianjun He*

Local generation of hydrogen for enhanced photothermal therapy, Nature Communications, 9(4241), 2018

DOI: 10.1038/s41467-018-06630-2

142. Zhen Gu* and Hongjie Dai*

The Inaugural Nano Research Young Innovators (NR45) Award in Nanobiotechnology, Nano Research, 10(4931), 2018 (Editorial)

DOI: 10.1007/s12274-018-2208-4

141. Ya-Nan Fan, Min Li, Ying-Li Luo, Qian Chen, Li Wang, Hou-Bing Zhang, Song Shen, Zhen Gu* and Jun Wang*

Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine, Biomaterials Science, 11(3009), 2018

DOI: 10.1039/C8BM00908B

140. Peng Xue, Lei Zhang, Zhigang Xu, Junjie Yan, Zhen Gu*, Yuejun Kang*

Blood sampling using microneedles as a minimally invasive platform for biomedical diagnostics, Applied Materials Today, 13(144), 2018

DOI: 10.1016/j.apmt.2018.08.013

139. Cong-Fei Xu, ZiDong Lu, Ying-Li Luo, Yang Liu, Zhiting Cao, Song Shen, Hong-Jun Li, Jing Liu, Kaige Chen, Zhiyao Chen, Xianzhu Yang, Zhen Gu, and Jun Wang*

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases, Nature Communications, 9(4092), 2018

DOI: 10.1038/s41467-018-06522-5

138. Xudong Zhang, Jinqiang Wang, Zhaowei Chen, Quanyin Hu, Chao Wang, Junjie Yan,Gianpietro Dotti, Peng Huang*, Zhen Gu*

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy, Nano Letters, 9(5716), 2018

DOI: 10.1021/acs.nanolett.8b02321

137. Qian Chen, Chao Wang, Guojun Chen, Quanyin Hu, Zhen Gu*

Delivery Strategy for Immune Checkpoint Blockade, Advanced Healthcare Materials, 20(1800424), 2018

DOI: 10.1002/adhm.201800424

136. Chao Wang+, Jinqiang Wang+, Xudong Zhang, Shuangjiang Yu, Di Wen, Quanyin Hu, Yanqi Ye, Hunter Bomba, Xiuli Hu, Zhuang Liu, Gianpietro Dotti, Zhen Gu*

In Situ Formed Reactive Oxygen Species-Responsive Scaffold with Gemcitabine and Checkpoint Inhibitor for Combination Therapy, Science Translational Medicine, 429(eaan3682), 2018

DOI: 10.1126/scitranslmed.aan3682

135. Zhaowei Chen+, Quanyin Hu+, Zhen Gu*

Leveraging Engineering of Cells for Drug Delivery, Accounts of Chemical Research, 3(668), 2018

DOI: 10.1021/acs.accounts.7b00526

134. Junjie Yan, Yue Lu, Min Yang*, Zhen Gu*

Advances in Liquid Metals for Biomedical Applications, Chemical Society Reviews, 8(2518), 2018

DOI: 10.1039/C7CS00309A

133. Zhen Gu*, Xiaoyuan Chen*

Towards Enhancing Skin Drug Delivery, Advanced Drug Delivery Reviews, 127(1), 2018

DOI: 10.1016/j.addr.2018.05.004

132. Shuangjiang Yu, Chao Wang, Jicheng Yu, Jinqiang Wang, Yue Lu, Yuqi Zhang, Xudong Zhang, Quanyin Hu, Wujin Sun, Chaoliang He*, Xuesi Chen*, Zhen Gu*

Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade, Advanced Mateirals, 28(1801527), 2018

DOI: 10.1002/adma.201801527

131. Yuqi Zhang, Jicheng Yu, Di Wen, Guojun Chen, Zhen Gu*

The Potential of a Microneedle Patch for Reducing Obesity, Expert Opinion on Drug Delivery, 5(431), 2018

DOI: 10.1080/17425247.2018.1449831

130. Guojun Chen, Jicheng Yu, Zhen Gu*

Glucose-Responsive Microneedle Patches for Diabetes Treatment, Journal of Diabetes Science and Technology, 1(41), 2019

DOI: 10.1177/1932296818778607

129. Xudong Zhang, Chao Wang, Jinqiang Wang, Quanyin Hu, Benjamin Langworthy, Yanqi Ye, Wujin Sun, Jing Lin, Tianfu Wang, Jason Fine, Hao Cheng, Gianpietro Dotti, Peng Huang*, Zhen Gu*

PD‐1 Blockade Cellular Vesicles for Cancer Immunotherapy, Advanced Materials, 22(1707112), 2018

DOI: 10.1002/adma.201707112

128. Quanyin Hu, Qian Chen, Zhen Gu*

Advances in Transformable Drug Delivery Systems, Biomaterials, 178(546), 2018

DOI: 10.1016/j.biomaterials.2018.03.056

127. Wenfei Chen, Ying Wang, Ming Qin, Xudong Zhang, Zhirong Zhang, Xun Sun*, Zhen Gu

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy, ACS Nano, 6(5995), 2018

DOI: 10.1021/acsnano.8b02235

126. Guang Yang, Yuqi Zhang, Zhen Gu*

Punching and Electroporation for Enhanced Transdermal Drug Delivery, Theranostics, 13 (3688), 2018

DOI: 10.7150/thno.27236

125. Yuqi Zhang+, Jinqiang Wang+*, Anna R. Kahkoska, John B. Buse, Zhen Gu*

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery, Small, 14(1704181), 2018

DOI: 10.1002/smll.201704181

124. Yuqi Zhang+, Peijian Feng+, Jicheng Yu, Jia Yang, Jiacheng Zhao, Jinqiang Wang*, Qundong Shen*, Zhen Gu*

ROS‐Responsive Microneedle Patch for Acne Vulgaris Treatment, Advanced Therapeutics, 3(1800035), 2018

DOI: 10.1002/adtp.201800035

123. Meng Liu†, Shiyang Shen†, Di Wen, Mengru Li, Teng Li, Xiaojie Chen, Zhen Gu*, Ran Mo*

Hierarchical Nanoassemblies-Assisted Combinational Delivery of Cytotoxic Protein and Antibiotic for Cancer Treatment, Nano Letters, 4(2294), 2018

DOI: 10.1021/acs.nanolett.7b04976

122. Yuqi Zhang, Jicheng Yu, Li Qiang*, Zhen Gu*

Nanomedicine for Obesity Treatment, Science China Life Sciences, 4(373), 2018

DOI: 10.1007/s11427-017-9257-1

121. Lulu Cai, Zhipeng Gu, Jian Zhong, Di Wen, Guojun Chen, Lin He, Jun Wu*, Zhen Gu*

Advances in Glycosylation-Mediated Cancer-Targeted Drug Delivery, Drug Discovery Today, 5(1126), 2018

DOI: 10.1016/j.drudis.2018.02.009

120. Jinqiang Wang, Yanqi Ye, Jicheng Yu, Anna R. Kahkoska, Xudong Zhang, Chao Wang, Wujin Sun, Ria D. Corder, Zhaowei Chen, Saad A. Khan, John B. Buse, Zhen Gu*

Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery, ACS Nano, 3(2466), 2018

DOI: 10.1021/acsnano.7b08152

119. Zhaowei Chen+, Jinqiang Wang+, Wujin Sun, Edikan Archibong, Anna R. Kahkoska, Xudong Zhang, Yue Lu, Frances S. Ligler, John B. Buse, Zhen Gu*

Synthetic beta cells for fusion-mediated dynamic insulin secretion, Nature Chemical Biology, 14(86), 2018

DOI: 10.1038/nchembio.2511

118. Yanqi Ye, Jicheng Yu, Di Wen, Anna R. Kahkoska, Zhen Gu*

Polymeric Microneedles for Transdermal Protein Delivery, Advanced Drug Delivery Reviews, 127(106), 2018

DOI: 10.1016/j.addr.2018.01.015

117. Jicheng Yu, Yuqi Zhang, Zhen Gu*

Advances in Bioresponsive Closed-loop Drug Delivery Systems, International Journal of Pharmaceutics, 2(350), 2018

DOI: 10.1016/j.ijpharm.2017.11.064

116. Ying-Li Luo, Cong-Fei Xu, Hong-Jun Li , Zhi-Ting Cao, Jing Liu, Ji-Long Wang, Xiao-Jiao Du, Xian-Zhu Yang*, Zhen Gu, and Jun Wang*

Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles, ACS Nano, 2(994), 2018

DOI: 10.1021/acsnano.7b07874

115. Chao Wang, Di Wen, Zhen Gu*

Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy, Bioconjugate Chemistry, 3(702), 2018

DOI: 10.1021/acs.bioconjchem.7b00619

114. Junnan Tang, Teng Su, Ke Huang , Phuong-Uyen Dinh, Zegen Wang, Adam Vandergriff, Michael T. Hensley, Jhon Cores, Tyler Allen, Taosheng Li, Erin Sproul, Emily Mihalko, Leonard J. Lobo, Laura Ruterbories, Alex Lynch, Ashely Brown, Thomas George Caranasos, Deliang Shen, George Andrew Stouffer, Zhen Gu, Jinying Zhang, Ke Cheng*

Targeted repair of heart injury by stem cells fused with platelet nanovesicles, Nature Biomedical Engineering, 2(17), 2018

DOI: 10.1038/s41551-017-0182-x

113. Shuangjiang Yu, Dianliang Zhang, Chaoliang He*, Wujin Sun, Rangjuan Cao, Shusen Cui, Mingxiao Deng, Zhen Gu*, Xuesi Chen*

Injectable Thermo-Sensitive Polypeptide-based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy, Biomacromolecules,12(4341), 2018

DOI: 10.1021/acs.biomac.7b01374

112. Junjie Yan, Jicheng Yu, Chao Wang, Zhen Gu*

Red Blood Cells for Drug Delivery, Small Methods, 12(1700270), 2017

DOI: 10.1002/smtd.201700270

111. Guang Yang, Yue Lu, Hunter N. Bomba, Zhen Gu*

Cysteine-rich Proteins for Drug Delivery and Diagnosis, Current Medicinal Chemistry, 24, 2017

DOI: 10.2174/0929867324666170920163156

110. Chunfang Gu, Hoai-Nghia Nguyen, Douglas Ganini, Zhaowei Chen, Henning J Jessen, Zhen Gu, Huanchen Wang, Stephen B Shears

KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 114(11968), 2017

DOI: 10.1073/pnas.1702370114

109. Yanqi Ye, Chao Wang, Xudong Zhang, Quanyin Hu, Yuqi Zhang, Qi Liu, Di Wen, Joshua Milligan, Adriano Bellotti, Leaf Huang, Gianpietro Dotti, Zhen Gu*

A Melanin-Mediated Cancer Immunotherapy Patch, Science Immunology, 2(eaan5692), 2017

DOI: 10.1126/sciimmunol.aan5692

108. Naveed Bakh, Mabel Cortinas, Michael Weiss, Robert Langer, Daniel Anderson, Zhen Gu, Sanjoy Dutta, Michael Strano*

Glucose responsive insulin by molecular and physical design, Nature Chemistry, 9(937), 2017

DOI: 10.1038/nchem.2857

107. Yuqi Zhang+, Qiongming Liu+, Jicheng Yu, Shuangjiang Yu, Jinqiang Wang, Li Qiang*, Zhen Gu*

Locally-Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment, ACS Nano, 11(9223), 2017

DOI: 10.1021/acsnano.7b04348

106. Yue Lu, Zhen Gu*

Kidney Physiology: A Size Bandpass Filter, Nature Nanotechnology, 12, 2017

DOI: 10.1038/nnano.2017.200

105. Jicheng Yu, Yuqi Zhang, Anna R. Kahkoska, Zhen Gu*

Bioresponsive Transcutaneous Patches, Current Opinion in Biotechnology, 48(28), 2017

DOI: 10.1016/j.copbio.2017.03.001

104. Jinqiang Wang, Yuqi Zhang, Edikan Archibong, Frances S. Ligler*, Zhen Gu*

Leveraging H2O2 Levels for Biomedical Applications, Advanced Biosystems, 1(9), 2017

DOI: 10.1002/adbi.201700084

103. Jicheng Yu, Yuqi Zhang, Wujin Sun, Anna R. Kahkoska, Jinqiang Wang, John B. Buse, Zhen Gu*

Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia, Small, 13(19), 2017

DOI: 10.1002/smll.201603028

102. Chao Wang, Wujin Sun, Yanqi Ye, Hunter N. Bomba, Zhen Gu*

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs, Theranostics, 7(3504), 2017

DOI: 10.7150/thno.19017

101. Yue Lu, Yiliang Lin, Zhaowei Chen, Yang Liu, Shuangjiang Yu, Wei Gao*, Michael D. Dickey*, Zhen Gu*

Enhanced Endosomal Escape by Light-fueled Liquid-metal Transformer, Nano Letters, 17(2138), 2017

DOI: 10.1021/acs.nanolett.6b04346

100. Xiuli Hu, Yuqi Zhang, Zhigang Xie, Xiabin Jing, Adriano Bellotti, Zhen Gu*

Stimuli-Responsive Polymersomes for Biomedical Applications, Biomacromolecules, 18(649), 2017

DOI: 10.1021/acs.biomac.6b01704

99. Chao Wang, Yanqi Ye, Wujin Sun, Jicheng Yu, Jinqiang Wang, David Lawrence, John Buse, Zhen Gu*

Red Blood Cells for Glucose-Responsive Insulin Delivery, Advanced Materials, 29(18), 2017

DOI: 10.1002/adma.201606617

98. Chao Wang, Yanqi Ye, Quanyin Hu, Adriano Bellotti, Zhen Gu*

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook, Advanced Materials, 29 (1606036), 2017

DOI: 10.1002/adma.201606036

97. Yuqi Zhang, Jicheng Yu, Anna Kahkoska, Zhen Gu*

Photoacoustic Drug Delivery, Sensors, 17, 2017

DOI: 10.3390/s17061400

96. Chao Wang, Wujin Sun, Yanqi Ye, Quanyin Hu, Hunter Bomba, Zhen Gu*

In situ Activation of Platelets with Checkpoint Inhibitors for Post-Surgical Cancer Immunotherapy, Nature Biomedical Engineering, 0011, 2017

DOI: 10.1038/s41551-016-0011

95. Jicheng Yu, Chenggen Qian, Yuqi Zhang, Zhen Cui, Yong Zhu, Qun-Dong Shen, Frances Ligler, John Buse, Zhen Gu*

Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery, Nano Letters, 17(733), 2017

DOI: 10.1021/acs.nanolett.6b03848

94. Chenggen Qian, Yulei Chen, Peijian Feng, Xuanzhong Xiao, Mei Dong, Jicheng Yu, Quanyin Hu, Qundong Shen*, Zhen Gu*

Conjugated Polymer Nanomaterials for Theranostics, Acta Pharmacologica Sinica, 38, 2017

DOI: 10.1038/aps.2017.42

93.Quanyin Hu, Wujin Sun, Chenggen Qian, Hunter N. Bomba, Hongliang Xin, Zhen Gu*

Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy, Advanced Materials, 29(1605803), 2017

DOI: 10.1002/adma.201605803

92. Ping’an Ma, Haihua Xiao, Chang Yu, Jianhua Liu, Ziyong Cheng, Haiqin Song, Xinyang Zhang, Chunxia Li, Jinqiang Wang, Zhen Gu*, Jun Lin*

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species, Nano Letters, 17(928), 2017

DOI: 10.1021/acs.nanolett.6b04269

91. Jin Di, Jicheng Yu, Qun Wang, Shanshan Yao, Dingjie Suo, Yanqi Ye, Matthew Pless, Yong Zhu, Yun Jing, Zhen Gu*

Ultrasound-Triggered Noninvasive Regulation of Blood Glucose Levels Using Microgels Integrated with Insulin Nanocapsules, Nano Research, 10(1393), 2017

DOI: 10.1007/s12274-017-1500-z

90. Chenggen Qian, Peijian Feng, Jicheng Yu, Yulei Chen, Quanyin Hu, Wujin Sun, Xuanzhong Xiao, Qun-Dong Shen*, Zhen Gu*

Anaerobe-inspired anticancer nanovesicles, Angewandte Chemie International Edition, 10(2588), 2017

DOI: 10.1002/anie.201611783

89. Wujin Sun, Zhen Gu*

Tailoring Non-Viral Delivery Vehicles for Transporting Genome-Editing Tools, Science China Materials, 60(6), 2017

DOI: 10.1007/s40843-016-5154-4

87. Yuqi Zhang, Jicheng Yu, Jinqiang Wang, Nicholas J. Hanne, Zheng Cui, Chenggen Qian, Chao Wang, Hongliang Xin, Jacqueline H. Cole, Caterina M. Gallippi*, Yong Zhu*, Zhen Gu*

Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation, Advanced Materials, 29(1604043), 2017

DOI: 10.1002/adma.201604043

88. Xiuli Hu, Jicheng Yu, Chenggen Qian, Yue Lu, Anna R. Kahkoska, Zhigang Xie, Xiabin Jing, John B. Buse, Zhen Gu*

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery, ACS Nano,11(613), 2017

DOI: 0.1021/acsnano.6b06892

86. Xudong Zhang, XinLiang, Jianjun Gu, Danfeng Chang, Jinxie Zhang, Zhaowei Chen, Yanqi Ye, Chao Wang, Wei Tao, Xiaowei Zeng, Gan Liu, Yongjun Zhang*, Lin Mei*, Zhen Gu*

Investigation and Intervention of Autophagy to Guide Cancer Treatment with Nanogels, Nanoscale, 9(150), 2017

DOI: 10.1039/C6NR07866D

85. Quanyin Hu, Zhen Gu*

Engineering Platelet-Mimicking Drug Delivery Vehicles, Frontiers of Chemical Science and Engineering,1, 2017

DOI: 10.1007/s11705-017-1614-6

84. Yue Lu, Alex Aimittee, Robert Langer*, Zhen Gu*

Bioresponsive Materials, Nature Reviews Materials, 1(16075), 2016

DOI: 10.1038/natrevmats.2016.75

83. Zhen Gu*

Introduction to special issue-Responsive Materials and Systems: Toward Smart and Precision Medications, Bioengineering and Translational Medicine, 1(235). 2016

DOI: 10.1002/btm2.10045

82. Yuqi Zhang+, Jicheng Yu+, Hunter Bomba, Yong Zhu*, Zhen Gu*

Mechanical Force-Triggered Drug Delivery, Chemical Reviews, 116(12536), 2016

DOI: 10.1021/acs.chemrev.6b00369

81. Yanqi Ye, Jinqiang Wang, Quanyin Hu, Gabrielle M. Hochu, Hongliang Xin, Chao Wang, Zhen Gu*

Synergistic transcutaneous immunotherapy enhances antitumor immune responses through delivery of checkpoint inhibitors, ACS Nano, 10(8956), 2016

DOI: 10.1021/acsnano.6b04989

80. Jicheng Yu, Xiuli Hu, Zhen Gu*

Stimuli-Responsive Delivery of Therapeutics for Diabetes Treatment, Bioengineering and Translational Medicine, 1(323), 2016

DOI: 10.1002/btm2.10036

79. Chao Wang*, Yanqi Ye, Zhen Gu*

Local Delivery of Checkpoints Antibodies, Human Vaccines & Immunotherapeutics, 13(245), 2016

DOI: 10.1080/21645515.2016.1223000

78. Quanyin Hu, Chenggen Qian, Wujin Sun, Jinqiang Wang, Zhaowei Chen, Hunter N. Bomba, Hongliang Xin, Qundong Shen, Zhen Gu*

Engineered Nano-platelets for Enhanced Treatment of Multiple Myeloma and Thrombus, Advanced Materials, 28(9573), 2016

DOI: 10.1002/adma.201603463

77. Lingyan Lv, Xin Liu, Baoyan Wang, Yan Jian, Wei Lv , Yue Zhao, Huihui Shi, Quanyin Hu, Hongliang Xin, Qunwei Xu*, Zhen Gu

Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles, Molecular Pharmaceutics, 13(3506), 2016

DOI: 10.1021/acs.molpharmaceut.6b00523

76. Yue Zhao, Yan Jiang, Wei Lv, Zhongyuan Wang, Lingyan Lv, Baoyan Wang, Xin Liu, Yang Liu, Quanyin Hu, Wujin Sun, Qunwei Xu, Hongliang Xin*, Zhen Gu

Dual Targeted Nanocarrier for Brain Ischemic Stroke Treatment, Journal of Controlled Release, 233(64), 2016

DOI: 10.1016/j.jconrel.2016.04.038

75. Chao Wang+, Yanqi Ye+, Gabrielle M. Hochu, Hasan Sadeghifar, Zhen Gu*

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody, Nano Letters, 16(2334), 2016

DOI: 10.1021/acs.nanolett.5b05030

74. Wujin Sun, Wenyan Ji, Quanyin Hu, Jicheng Yu, Chao Wang, Chenggen Qian, Gabrielle Hochu, Zhen Gu*

Transformable DNA Nanocarriers for Plasma Membrane Targeted Delivery of Cytokines, Biomaterials, 96(1), 2016

DOI: 10.1016/j.biomaterials.2016.04.011

73. Jicheng Yu, Yuqi Zhang, Xiuli Hu, Wujin Sun, Chao Wang, Yanqi Ye, Yuyan Weng, Zhen Gu*

Internalized Compartments Encapsulated Nanogels for Targeted Drug Delivery, Nanoscale, 8(9178), 2016

DOI: 10.1039/C5NR08895J

71. Chenggen Qian+, Jicheng Yu+, Yulei Chen+, Quanyin Hu, Xuanzhong Xiao, Wujin Sun, Chao Wang, Qun-Dong Shen*, Zhen Gu*

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy, Advanced Materials, 28(3313), 2016

DOI: 10.1002/adma.201505869

72. Chenggen Qian, Yulei Chen, Sha Zhu, Jicheng Yu, Lei Zhang, Peijian Feng, Xin Tang, Xuanzhong Xiao, Qun-Dong Shen*, Zhen Gu*

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging, Theranostics, 6(1053), 2016

DOI: 10.7150/thno.14843

70. Jicheng Yu, Zhen Gu*

Hypoxia-Sensitive Materials for Biomedical Applications, Annals of Biomedical Engineering, 44(1931), 2016

DOI: 10.1007/s10439-016-1578-6

69. Wujin Sun, Wenyan Ji, Quanyin Hu, Zhen Gu*

Leveraging Physiology for Precision Drug Delivery, Physiological Reviews, 97(189), 2017

DOI: 10.1152/physrev.00015.2016

68. Yanqi Ye+, Jicheng Yu+, Chao Wang, Nhu-Y Nguyen, Glenn M. Walker, John B. Buse, Zhen Gu*

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose‐Signal Amplifiers for Smart Insulin Delivery, Advanced Materials, 28(3115), 2016

DOI: 10.1002/adma.201506025

67. Ran Mo, Zhen Gu*

Tumor Microenvironment and Intracellular Signal-Activated Nanomaterials for Anticancer Drug Delivery, Materials Today, 19(274), 2016

DOI: 10.1016/j.mattod.2015.11.025

66. Quanyin Hu, Wujin Sun, Yue Lu, Hunter Bomba, Yanqi Yue, Tianyue Jiang, Ari Isaacson, Zhen Gu*

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots, Nano Letters, 16(1118), 2016

DOI: 10.1021/acs.nanolett.5b04343

65. Chao Wang, Wujin Sun, Yanqi Ye, Grace Wright, Andrew Wang, Zhen Gu*

Inflammation‐Triggered Cancer Immunotherapy by Programmed Delivery, Advanced Materials, 28(8912), 2016

DOI: 10.1002/adma.201506312

64. Dongquan Shi, Xingquan Xu, Yanqi Ye, Kai Song, Yixiang Cheng, Jin Di, Quanyin Hu, Jianxin Li, Huangxian Ju, Qing Jiang*, Zhen Gu*

Photo-Crosslinked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration, ACS Nano, 10(1292), 2016

DOI: 10.1021/acsnano.5b06663

63. Yuqi Zhang, Yong Zhu*, Zhen Gu*

Elastic Drug Delivery: could treatments be triggered by patient movement?, Nanomedicine, 11(323), 2016

DOI: 10.2217/nnm.15.197

62. Wujin Sun, Zhen Gu*

ATP-Responsive Drug Delivery Systems, Expert Opinion on Drug Delivery, 13(311), 2016

DOI: 10.1517/17425247.2016.1140147

61. Yue Lu, Quanyin Hu, Yiliang Lin, Dennis B. Pacardo, Chao Wang, Wujin Sun, Frances S. Ligler, Michael D. Dickey, Zhen Gu*

Transformable Liquid-Metal Nanomedicine, Nature Communications, 6(10066), 2015

DOI: 10.1038/ncomms10066

60. Jicheng Yu, Yuqi Zhang, Yanqi Ye, Rocco DiSanto, Wujin Sun, Davis Ranson, Frances Ligler, John Buse, Zhen Gu*

Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles Provide Fast Glucose-Responsive Insulin Delivery, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 112(8260), 2015

DOI: 10.1073/pnas.1505405112

59. Quanyin Hu, Wujin Sun, Chao Wang, Zhen Gu*

Recent Advances in Cocktail chemotherapy by Combination Drug Delivery Systems, Advanced Drug Delivery Reviews, 98(19), 2015

DOI: 10.1016/j.addr.2015.10.022

58. Quanyin Hu, Wujin Sun, Chenggen Qian, Chao Wang, Hunter Bomba, Zhen Gu*

Anticancer Platelet-Mimicking Nanovehicles, Advanced Materials, 27(7043), 2015

DOI: 10.1002/adma.201503323

57. Wujin Sun, Wenyan Ji, Jordan M. Hall, Quanyin Hu, Chao Wang, Chase L. Beisel*, Zhen Gu*

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing, Angewandte Chemie International Edition, 127(12197), 2015

DOI: 10.1002/ange.201506030

56. Yanqi Ye, Jicheng Yu, Zhen Gu*

Versatile Protein Nanogels Prepared by In Situ Polymerization, Macromolecular Chemistry and Physics, 217(333), 2015

DOI: 10.1002/macp.201500296

55. Jin Di, Shanshan Yao, Yanqi Ye, Zheng Cui, Jicheng Yu, Tushar K. Ghosh, Young Zhu*, Zhen Gu*

Stretch-Triggered Drug Delivery from Wearable Elastomer Containing Therapeutic Depots, ACS Nano, 9(9407), 2015

DOI: 10.1021/acsnano.5b03975

54. Bingxi Yan, Boyi Li, Forest Kunecke, Zhen Gu, Liang Guo*

Polypyrrole-Based Implantable Electroactive Pump for Controlled Drug Microinjection, ACS Applied Materials & Interfaces, 7(14563), 2015

DOI: 10.1021/acsami.5b04551

53. Samir Mitragotri*, Daniel G. Anderson, Shawn X. Chen, Edward K. Chow, Dean Ho, Alexander V. Kabanov, Jeffrey M. Karp, Kazunori Kataoka, Chad A. Mirkin, Sarah Hurst. Petrosko, Jinjun Shi, Molly M. Stevens, Shouheng Sun, Sweehin Teoh, Subbu S. Venkatraman, Younan Xia, Shutao Wang, Zhen Gu*, Chenjie Xu*

Accelerating the Translation of Nanomaterials in Biomedicine, ACS Nano, 9(6644), 2015

DOI: 10.1021/acsnano.5b03569

52. Jin Di, Jinwook Kim, Quanyin Hu, Xiaoning Jiang*, Zhen Gu*

Spatiotemporal Drug Delivery Using Laser-Generated-Focused Ultrasound System, Journal of Controlled Release, 220(592), 2015

DOI: 10.1016/j.jconrel.2015.08.033

51. Xiaohui Li, Jicheng Yu, Naiyan Lu, Yuyan Weng*, Weidong Zhang, Zhijun Hu, Yuqiang Ma, Zhen Gu*

Confinement-Induced Nanocrystal Alignment of Conjugated Polymer by the Soft-Stamped Nanoimprint Lithography, Chinese Physics B, 24(10), 2015

DOI: 10.1088/1674-1056/24/10/104215

50. Wujin Sun, Yue Lu, Zhen Gu*

Rolling Circle Replication for Engineering Drug Delivery Carriers, Editorial for Therapeutic Delivery, 6(765), 2015

DOI: 10.4155/tde.15.27

49. Jin Di, Jicheng Yu, Yanqi Ye, Davis Ranson, Abby Jindal, Zhen Gu*

Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles, Cellular and Molecular Bioengineering, 8(445), 2015

DOI: 10.1007/s12195-015-0390-y

48. Dennis B. Pacardo, Bhanu Neupane, S. Michaela Rikard, Yue Lu, Ran Mo, Sumeet R. Mishra, Joseph B. Tracy, Gufeng Wang, Frances S. Ligler,* and Zhen Gu*

Dual Wavelength-Activatable Gold Nanorods Complex for Synergistic Cancer Treatment, Nanoscale , 7(12096), 2015

DOI: 10.1039/C5NR01568E

47. Wenyan Ji, Wujin Sun, Jinmei Feng, Tianshun Song, Dalu Zhang, Pingkai Ouyang, Zhen Gu, Jingjing Xie*

Characterization of a novel N-acetylneuraminic acid lyase favoring N-acetylneuraminic acid synthesis, Scientific Reports, 5(9341), 2015

DOI: 10.1038/srep09341

46. Tianyue Jiang, Wujin Sun, Nancy A. Burns, Saad A. Khan, Ran Mo, Zhen Gu*

Furin-Mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene, Advanced Materials, 27(1021), 2015

DOI: 10.1002/adma.201404498

45. Dennis Pacardo, Frances Ligler*, Zhen Gu*

Programmable Nanomedicine: Synergistic and Sequential Drug Delivery Systems, Nanoscale, 7(3381), 2015

DOI: 10.1039/C4NR07677J

44. Ran Mo, Tianyue Jiang, Wujin Sun, Zhen Gu*

ATP-Responsive DNA-Graphene Hybrid Nanoaggregates for Anticancer Drug Delivery, Biomaterials, 50(67), 2015

DOI: 10.1016/j.biomaterials.2015.01.053

43. Yuqi Zhang, Jicheng Yu, Qundong Shen, Zhen Gu*

Glucose-Responsive Synthetic Closed-Loop Insulin Delivery Systems, Progress in Chemistry, 1(11), 2015

DOI: 10.7536/PC140942

42. Wujin Sun, Zhen Gu*

Engineering DNA-Scaffolds for Delivery of Anticancer Therapeutics, Biomaterials Science, 3(1018), 2015

DOI: 10.1039/C4BM00459K

41. Rocco DiSanto, Vinayak Subramanian, Zhen Gu*

Recent advances in nanotechnology for diabetes treatment, WIREs Nanomedicine & Nanobiotechnology, 7(548), 2015

DOI: 10.1002/wnan.1329

40. Wujin Sun, Tianyue Jiang, Yue Lu, Margaret Reiff, Ran Mo, Zhen Gu*

Cocoon-like Self-Degradable DNA-Nanoclew for Anticancer Drug Delivery, Journal of the American Chemical Society, 136(14722), 2014

DOI: 10.1021/ja5088024

39. Wanyi Tai, Ran Mo, Jin Di, Vinayak Subramanian, Xiao Gu, John Buse, Zhen Gu*

Bio-Inspired Synthetic Nanovesicles for Glucose-Responsive Release of Insulin, Biomacromolecules, 15(3495), 2014

DOI: 10.1021/bm500364a

38. Ran Mo, Tianyue Jiang, Jin Di, Wanyi Tai, Zhen Gu*

Emerging Micro- and Nanotechnology Based Synthetic Approaches for Insulin Delivery, Chemical Society Reviews, 43(3595), 2014

DOI: 10.1039/C3CS60436E

37. Yue Lu, Ran Mo, Wanyi Tai, Wujin Sun, Dennis B. Pacardo, Chenggen Qian, Qundong Shen, Frances S. Ligler, Zhen Gu*

Self-Folded Redox/pH Dual-Responsive Nanocarriers for Anticancer Drug Delivery, Chemical Communications, 50(15105), 2014

DOI: 10.1039/C4CC07004F

36. Muxun Zhao, Yarong Liu, Renee Hsieh, Nova Wang, Wanyi Tai, Kye-ll Joo, Pin Wang, Zhen Gu, Yi Tang*

Clickable Protein Nanocapsules for Targeted Delivery of Recombinant p53 Protein, Journal of the American Chemical Society, 136(15309), 2014

DOI: 10.1021/ja508083g

35. Quanyin Hu, Prateek Katti, Zhen Gu*

Enzyme-Responsive Nanomaterials for Controlled Drug Delivery, Nanoscale, 6(12273), 2014

DOI: 10.1039/C4NR04249B

34. Ran Mo, Tianyue Jiang, Zhen Gu*

Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery, Angewandte Chemie International Edition, 53(5810), 2014

DOI: 10.1002/anie.201400268

33. Ran Mo, Tianyue Jiang, Rocco DiSanto, Wanyi Tai, Zhen Gu*

ATP-Triggered Anticancer Drug Delivery, Nature Communications, 5, 3364, 2014.

DOI: 10.1038/ncomms4364

Yue Lu, Wujin Sun, Zhen Gu*

Stimuli-Responsive Nanomaterials for Therapeutic Protein Delivery, Journal of Controlled Release, 194(1), 2014

DOI: 10.1016/j.jconrel.2014.08.015

31. Wanyi Tai, Ran Mo, Yue Lu, Tianyue Jiang, Zhen Gu*

Folding Graft Copolymer with Pendant Drug Segment for Co-Delivery of Anticancer Drugs, Biomaterials, 35(7194), 2014

DOI: 10.1016/j.biomaterials.2014.05.004

30. Dennis Pacardo, Bhanu Nupane, Gufeng Wang, Zhen Gu, Glenn Walker, Frances Ligler*

A Temperature Microsensor for Measuring Laser-Induced Heating in Gold Nanorods, Analytical & Bioanalytical Chemistry, 407(719), 2015

DOI: 10.1007/s00216-014-8222-9

29. Wujin Sun, Yue Lu, Zhen Gu*

Advances in Anticancer Protein Delivery using Micro-/Nanoparticles, Particle, 31(1204), 2014

DOI: 10.1002/ppsc.201400140

28. Jicheng Yu, Yu-Lei Chen, Yu-Qi Zhang, Xi-Kuang Yao, Cheng-Gen Qian, Jun Huang, Sha Zhu, Xi-Qun Jiang, Qun-Dong Shen*, Zhen Gu*

pH-Responsive and Near-Infrared-Emissive Polymer Nanoparticles for Simultaneous Delivery, Release, and Fluorescence Tracking of Doxorubicin in vivo, Chemical Communications, 50(4699), 2014

DOI: 10.1039/C3CC49870K

27. Ran Mo, Tianyue Jiang, Zhen Gu*

Recent Progress in Multi-Drug Delivery to Cancer Cells by Liposomes, Nanomedicine, 9(1117), 2014

DOI: 10.2217/nnm.14.62

26. Yizhou Dong, Ahmed A. Eltoukhy, Christopher A. Alabi, Omar F. Khan, Omid Veiseh, J. Robert Dorkin, Sasilada Sirirungruang, Hao Yin, Benjamin C. Tang, Jeisa M. Pelet, Delai Chen, Zhen Gu, Yuan Xue, Robert Langer, Daniel G. Anderson*

Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo, Advanced Healthcare Materials, 3(1392), 2014

DOI: 10.1002/adhm.201400054

25. Ying Chen, Jingya Nan, Yue Lu, Chunpeng Wang, Fuxiang Chu, Zhen Gu*

Hybrid Fe3O4-Poly (Acrylic Acid) Nanogels for Theranostic Cancer Treatment, Journal of Biomedical Nanotechnology, 11(771), 2014

DOI: 10.1166/jbn.2015.2001

24. Tianyue Jiang+, Ran Mo+, Adriano Bellotti, Jianping Zhou, Zhen Gu*

Gel-Liposome-Mediated Co-Delivery of Anticancer Membrane-Associated Proteins and Small-Molecule Drugs for Enhanced Therapeutic Efficacy, Advanced Functional Materials, 24(2295), 2014

DOI: 10.1002/adfm.201303222

23. Jin Di, Jennifer Price, Xiaoning Jiang, Yun Jing, Zhen Gu*

Ultrasound-Triggered Regulation of Blood Glucose Levels Using Nano-Network, Advanced Healthcare Materials, 3(811), 2014

DOI: 10.1002/adhm.201300490

22. Zhen Gu, Tram T. Dang, Minglin Ma, Benjamin C. Tang, Hao Cheng, Shan Jiang, Yizhou Dong, Yunlong Zhang, Daniel G. Anderson*

Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery, ACS Nano, 7(6758), 2013

DOI: 10.1021/nn401617u

21. Yunlong Zhang, Jeisa M. Pelet, Daniel A. Heller, Yizhou Dong, Delai Chen, Zhen Gu , Brian J. Joseph, Jasmine Wallas, and Daniel G. Anderson*

Lipid-Modified Aminoglycoside Derivatives for in vivo siRNA Delivery, Advanced Materials, 25(4641), 2013

DOI: 10.1002/adma.201301917

20. Qun Wang, Zhen Gu, Syed Jamal, Michael S. Detamoreand Cory Berkland

Hybrid Hydroxyapatite Nanoparticle Colloidal Gels are Injectable Fillers for Bone Tissue Engineering, Tissue Engineering, 19(2586), 2013

DOI: 10.1089/ten.tea.2013.0075

19. Zhen Gu, Alex Aimetti, Qun Wang, Tram T. Dang, Yunlong Zhang, Omid Veiseh, Hao Cheng, Robert Langer, Daniel G. Anderson

Injectable Nano-Network for Glucose-Mediated Insulin Delivery, ACS Nano, 7(4194), 2013

DOI: 10.1021/nn400630x

18. Tram T. Dang, Anh V. Thai, Jeremy E. Slosberg, Joshua Cohen,, Minglin Ma, Joshua Doloff, Jennifer Hollister-Lock, Zhen Gu, Hao Cheng, Gordon Weir, Robert Langer, Daniel G. Anderson

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug, Biomaterials, 34(5792), 2013

DOI: 10.1016/j.biomaterials.2013.04.016

17. Muxun Zhao, Biliang Hu, Zhen Gu, Kye-ll Joo, Pin Wang, Yi Tang

Degradable Polymeric Nanocapsule for Efficient Intracellular Delivery of a High Molecular Weight Tumor-Selective Protein Complex, Nano Today, 8(11), 2013

DOI: 10.1016/j.nantod.2012.12.003

16. Zhen Gu*, Anuradha Biswas, Muxun Zha, Yi Tang*

Tailoring Nanocarriers for Intracellular Protein Delivery, Chemical Society Reviews, 40(3638), 2011

DOI: 10.1039/C0CS00227E

15. Muxun Zhao, Anuradha Biswas, Biliang Hu, Kye-Il Joo, Pin Wang, Zhen Gu*, Yi Tang*

Redox-Responsive Nanocapsules for Intracellular Protein Delivery, Biomaterials, 32(5223), 2011

DOI: 10.1016/j.biomaterials.2011.03.060

14. Kye-Il Joo, Yun Fang, Yarong Liu, Liang Xiao, Zhen Gu, April Tai, Chi-Lin Lee, Yi Tang, Pin Wang*

Enhanced Real-Time Monitoring of Adeno-Associated Virus Trafficking by Virus-Quantum Dot Conjugates, ACS Nano, 5(3523), 2011

DOI: 10.1021/nn102651p

13. Zhen Gu*, Muxun Zhao, Yuewei Sheng, Laurent A. Bentolila, Yi Tang*

Detection of Mercury Ion by Infrared Fluorescent Protein and Its Hydrogel-Based Paper Assay, Analytical Chemistry, 83(2324), 2011

DOI: 10.1021/ac103236g

12. Anuradha Biswas , Kye-Il Joo, Jing Liu , Muxun Zhao , Guoping Fan , Pin Wang , Zhen Gu* , Yi Tang*

Endoprotease-Mediated Intracellular Protein Delivery Using Nanocapsules, ACS Nano, 5 (1385), 2011

DOI: 10.1021/nn1031005

11. Bin Sun, Min-Jie Sun, Zhen Gu, Qun-Dong Shen*, Shao-Jun Jiang, Yu Wang Macromolecules

Conjugated Polymer Fluorescence Probe for Intracellular Imaging of Magnetic Nanoparticles, Macromolecules, 43 (10348), 2010

DOI: 10.1021/ma101680g

10. Zhen Gu, Anuradha Biswas, Kye-Il Joo, Biliang Hu, Pin Wang, Yi Tang*

Probing Protease Activity by Single-Fluorescent-Protein Nanocapsules, Chemical Communications, 46 (6467), 2010

DOI: 10.1039/C0CC01439G

9. Zhen Gu* and Yi Tang*

Enzyme-Assisted Photolithography for Spatial Functionalization of Hydrogels, Lab on a Chip, 10 (1946), 2010

DOI: 10.1039/C001335H

8. Zhen Gu, Xiao-Yuan Chen, Qun-Dong Shen, Hai-Xiong Ge, Hai-Hua Xu

Hybrid Nanocomposites of Semiconductor Nanoparticles and Conjugated Polyelectrolytes and Their Application as Fluorescence Biosensors, Polymer, 51 (902), 2010

DOI: 10.1016/j.polymer.2009.12.035

7. Ming Yan+, Juanjuan Du+, Zhen Gu, Min Liang, Yufang Hu, Wenjun Zhang, Tatiana Segura, Zheng Liu, Yi Tang*, Yunfeng Lu*

A Novel Intracellular Protein Delivery Platform Based on Single-Protein Nanocapsules, Nature Nanotechnology, 5(48), 2010

DOI: 10.1038/nnano.2009.341

6. Zhen Gu, Ming Yan, Biliang Hu, Kye-Il Joo, Anuradha Biswas, Yu Huang, Yunfeng Lu*, Pin Wang* and Yi Tang*

Protein Nanocapsule Weaved with Enzymatically Degradable Polymeric Network, Nano Letters, 12(4533), 2009

DOI: 10.1021/nl902935b

5. Zhen Gu*, Suxian Huang, Yong Chen*

Biomolecular Nanopatterning by Magnetic Electric Lithography, Angewandte Chemie International Edition, 48(952), 2009

DOI: 10.1002/anie.200803456

4. Lei Zhang, Zhen Gu, Zhiping Yu, Xiangqing He, and Yong Chen

A CMOS Microarray with On-chip Decoder/Amplifier and Its Integration with Bio-Nano-System, Journal of Semiconductors, 29(1947), 2008

3. Qianxi Lai, Zhiyong Li, Lei Zhang, Xuema Li, William F. Stickle, Zuhua Zhu, Zhen Gu, Theodore I. Kamins, R. Stanley Williams, and Yong Chen*

An Organic/Si Nanowire Hybrid Field Configurable Transistor, Nano Letters, 3(876), 2008

DOI: 10.1021/nl073112y

2. Zhen Gu, Yong-Jun Bao, Yang Zhang, Mu Wang, Qun-Dong Shen*

Anionic Water-Soluble Poly(phenylenevinylene) Alternating Copolymer: High-Efficiency Photoluminescence and Dual Electroluminescence, Macromolecules, 39 (3125), 2006

DOI: 10.1016/j.icheatmasstransfer.2016.12.017

1. Zhen Gu, Qun-Dong Shen*, Juan Zhang, Chang-Zheng Yang

Dual Electroluminescence from a Single-Component Light-emitting Electrochemical Cell Based on Water-Soluble Conjugated Polymer, Journal of Applied Polymer Science, 100(2930), 2006

DOI: doi.org/10.1002/app.22510